Geneless optostimulation in the heart: using light to control the activity of cardiac cells
Francesco Lodola a
a University of Milano Bicocca, Via Roberto Cozzi, 55, Milano, Italy
Materials for Sustainable Development Conference (MATSUS)
Proceedings of MATSUS Fall 2023 Conference (MATSUSFall23)
#BIOMAT - Next Generation Bio-hybrid, Bio-inspired and Bio-enabled Materials
Torremolinos, Spain, 2023 October 16th - 20th
Organizers: Giuseppe Maria Paternò and Vito Vurro
Invited Speaker, Francesco Lodola, presentation 149
DOI: https://doi.org/10.29363/nanoge.matsus.2023.149
Publication date: 18th July 2023

The use of light to control the activity of different cell-types has recently come at the forefront of the scientific community thanks to a series of key-enabling features (i.e. spatial/temporal selectivity, and lower invasiveness). Optogenetics is probably the prime example of this approach and since its initial development in neuroscience has been extended to other fields. However, the need of viral gene transfer, required to induce light-sensitivity in the target organism, strongly impairs the clinical translation of optogenetics-based systems. To overcome this issue, non-genetic (geneless) optostimulation is a growing and multidisciplinary field of research at the border among physics, material science and biology that aims to achieve light sensitivity with photoactive actuators. I will present promising photoactuators for cardiac applications, focusing in particular on excitation-contraction coupling modulation. Future clinical perspectives in contexts where the possibility of obtaining precise control of cardiac cell activity could offer new insights (e.g. resynchronization and arrhythmia termination) will also be discussed.

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