Proceedings of MATSUS Fall 2023 Conference (MATSUSFall23)
DOI: https://doi.org/10.29363/nanoge.matsus.2023.073
Publication date: 18th July 2023
The effectiveness of many chemotherapeutic agents in treating cancer is limited by poor delivery efficiency and systemic toxicity. Local chemotherapy approaches utilizing iontronic devices present a promising solution for efficient interference with cancer growth and tumor size reduction. We use iontronic devices with incorporated membranes to enable the continuous delivery of chemotherapeutics with high spatiotemporal resolution. We operate freestanding iontronic pumps with the the chemotherapeutics Gemcitabe (Gem) named GemIPs to treat a GBM model on the chicken chorioallantoic membrane. In addition, we compare results with a conventional topical daily treatment. We see that both administration techniques induce G2-phase cell cycle arrest and apoptosis. Remarkably, growth inhibition was achieved only with the steady Gem dosing with GemIPs, but not with daily topical drug administration at the maximum dosage amounts that was not lethal for the chick embryo. I will discuss how the different transient concentration profiles between the techniques generates this difference in outcome.
We gratefully acknowledge the support of the Ph.D. programs Molecular Medicine (MOLMED) and
Metabolic and Cardiovascular Disease (DK-MCD) of the Medical University of Graz, as well as the Austrian
Science Fund (FWF) through project grant TAI 245 and European Innovation council 101099963 to R. Schindl
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