DOI: https://doi.org/10.29363/nanoge.obe.2022.009
Publication date: 14th January 2022
In drug-resistant partial epilepsies, resective surgery is the treatment of choice to suppress seizures, provided that the epileptogenic zone (EZ) is clearly identified and that it can be safely removed. In this context, the capacity to rely on objective biomarkers of the EZ is fundamental to define the optimal surgical approach in the specific context of each patient. One of the most important biomarkers are electrophysiological signals which represent local field potential variations generated by a network of neurons. Here our focus is a specific oscillation band knows as fast ripple (FR) with the frequency band between 250 Hz to 600 Hz. FRs are transit signals which mixed with ongoing activities and last only few tens of millisecond. There are fundings that show FRs are specific to epileptogenic zone. However, routine clinical use of FRs is a long path since we do not know which information is carried by FRs and how FRs correlates with epileptogenic seizure [1] .
The aim of this project is to optimize the recording electrodes properties to improve the detection of epileptic FRs. In first stage we benefited from the epileptic computational mode and tuned the electrode’s characteristics including size, impedance, geometry, and material. According to the simulated results, microelectrodes are fabricated. The impedance of electrodes were tuned by controlling the electrodeposition of PEDOT:PSS conductive polymer. Electrode’s recording sites are characterized in terms of morphology, impedance, electricidal conductivity, uv-visible and furrier transform infrared transmission. The double layer capacitance of the electrodes was measured experimentally and modeled with an equivalent circuit [2-3].
In the next step, microelectrodes are implanted in kainate mouse model of temporal lobe epilepsy for 28 days. The recorded signals are segmented and processed to extract the fast ripples. We found that the amplitude of the FRs signals to the background activity increases by lowering the impedance. In addition, the cut-off frequency at which electrodes the electrode transits from predominantly resistive to capacitive, highly influence the FRs resolvability.
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