DOI: https://doi.org/10.29363/nanoge.obe.2022.001
Publication date: 14th January 2022
Bioelectronic devices have found use at the interface with neural tissue to investigate and treat nervous system disorders. We have developed and characterized a very thin flexible polyimide-based bioelectronic implant that is inserted along the thoracic spinal cord in rats directly in contact with the dorsal surface of the spinal cord. There was no negative impact on hind-limb functionality nor any change in the volume or shape of the spinal cord. The bioelectronic implant was maintained in rats for a period of 3 months. We have obtained the first subdural recordings of spinal cord activity in freely moving animals. Recordings contained multiple distinct voltage waveforms spatially localized to individual electrodes. A clinically relevant spinal contusion injury can be achieved with the implant in place. This device has great potential to monitor electrical signaling in the spinal cord after an injury, and in the future, this implant will facilitate the identification of biomarkers in spinal cord injury and recovery. We are exploring further development of this implant to deliver localized treatments to the spinal cord towards regeneration of damaged tissues to recover lost function. Localized therapies are being developed in the form of pharmaceutical treatment through the local delivery of neurotrophic factors, and electroceutical treatment through precise electrical field stimulation.
Funding is acknowledged from the Health Research Council of New Zealand, the CatWalk Spinal Cord Injury Research Trust, and the Neurological Foundation of New Zealand.
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