Proceedings of nanoGe Spring Meeting 2022 (NSM22)
DOI: https://doi.org/10.29363/nanoge.nsm.2022.071
Publication date: 7th February 2022
H2O2 plays a significant role in a vast range of physiological processes in aerobic environments where it is produced by cells and performs vital tasks in redox signaling. The sensitivity of many biological signaling pathways to H2O2 opens up a unique direction in the development of bioelectronics devices to control levels of reactive-oxygen species (ROS). Here we present a microfabricated ROS modulation device which relies on controlled faradaic reactions. We report a concentric pixel arrangement of a peroxide-evolving cathode surrounded by an anode ring which decomposes the peroxide, resulting in localized peroxide delivery. We exploit the conducting polymer (poly(3,4-ethylenedioxythiophene), PEDOT, as the cathode. PEDOT selectively catalyzes the oxygen reduction reaction resulting in the production of hydrogen peroxide (H2O2) via a two-electron pathway. To complete the pixel, a palladium anode is used to catalytically consume peroxide. Using electrochemical and optical assays, combined with computational modeling, we benchmark the performance of the devices. The concentric pixels generate tunable gradients of peroxide and oxygen concentrations. We prototype the faradaic pixel devices by successfully modulating human H2O2-sensitive Kv7.2/7.3 (M-type) channels expressed in a single-cell model (Xenopus laevis oocytes). The Kv7 ion channel family is responsible for regulating action potential firing and neuronal excitability in various tissues as the heart, brain, and vascular smooth muscles, making it an ideal testing platform for faradaic ROS stimulation. We present also a wireless, light-driven version of this device. Our results demonstrate the potential of PEDOT to act as a H2O2 delivery system, paving the way to novel ROS-based organic bioelectronics.
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