Synthesis, ion diffusion and biofunctionalization of quantum dots
Horst Weller a
a University of Hamburg, Grindelallee 117, Hamburg, Germany
Materials for Sustainable Development Conference (MATSUS)
Proceedings of September Meeting 2016 (NFM16)
Berlin, Germany, 2016 September 5th - 13th
Organizers: Marin Alexe, Enrique Cánovas, Celso de Mello Donega, Ivan Infante, Thomas Kirchartz, Maksym Kovalenko, Federico Rosei, Lukas Schmidt-Mende, Laurens Siebbeles, Peter Strasser, Teodor K Todorov, Roel van de Krol and Ulrike Woggon
Invited Speaker, Horst Weller, presentation 152
Publication date: 14th June 2016

The key idea for using nanocrystals for biomedical diagnostics is to benefit from their outstanding physical properties in the visualization of biological events or malignant cells or tissues. This requires a special design of the ligand shell, which preserves the fluorescent, magnetic and plasmonic properties of the particles in the biological environment on one side and allows a specific targeting on the other. The lecture reports on different chemical approaches and describes factors determining the biological response on fully synthetic nanocrystals. We will highlight concepts based on PEGylation and show how small deviations in the ligand shell alters the behavior in biological environment substantially. Moreover, we will present combinatorial approaches for the functionalization of the nanocrystals with biological affinity molecules to improve targeting specifity and concepts to optimize the physical properties of the inorganic core to increase the sensitivity for the respective imaging techniques.



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