Proceedings of nanoGe September Meeting 2015 (NFM15)
Publication date: 8th June 2015
A current research challenge is to develop nanostructures and nanoparticles, that can be used as imaging agents and therapeutics, accessible at the subcellular level with high specificity of targeting and interaction, in order to infer complex events that occur within living cells and to design therapies for the treatments of specific diseases.[1] Mitochondria represent an attractive subcellular target. Its active targeting has been achieved by exploiting the selective recognition of the translocator protein (TSPO), a receptor mainly located in the outer mitochondrial membrane, whose biological role is associated to the mitochondria function and to cancer and neurodegenerative diseases. Small high binding molecules have been developed for TSPO and used for positron emission tomography (PET), magnetic resonance (MR) and fluorescent imaging, which represents a sensitive, selective, rich in contrast and versatile spectroscopies. In this regards, here a novel, robust nanostructure has been proposed as fluorescent agent, by using semiconductor nanocrystals (QDs) as fluorescence (PL) probes. Such a nanostructure takes advantage of the NP photophysical properties and versatile surface chemistry, for the growing up of a multifunctional structure able to selectively target and recognize the mithocondria. Amine functionalized luminescent silica coated (CdSe)ZnS QDs (QDs@SiO2) have been purposely synthesized [2] and conjugated to a synthetic TSPO ligand, characterized by a 2-phenyl-imidazo[1,2-a]pyridine acetamide structure, resulting in a single nano-object, where the selectivity of the ligand towards TSPO and the photostability and high PL of QDs are effectively conveyed. Results of morphological and optical characterization elucidate the chemical and physical properties of the prepared nanostructures, while in vitro study by subcellular fractionation, confocal scanning microscopy PL and co-localization analysis demonstrate that they can effectively target the mitochondria.
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