Proceedings of MATSUS Spring 2025 Conference (MATSUSSpring25)
DOI: https://doi.org/10.29363/nanoge.matsusspring.2025.509
Publication date: 16th December 2024
The application of Metal-organic frameworks (MOFs), especially nanoscale MOFs, in biomedicine has become a rapidly developing hot research topic in the last years. This interest arises from their unique properties, mainly their high chemical and structural diversity, tunability, and potential multifunctionality. Since the structure of the MOF will directly influence its properties, function, and biological performance, each MOF must be designed specifically for each target application. In this direction, the engineering of MOFs involves the incorporation of functional units to endow them with new properties and functions, with the ultimate aim of developing novel MOF-based nanoplatforms with improved performances for some specific applications. There is a wide variety of interesting functional units that can be smartly combined with MOFs, ranging from metallic nanoparticles, to polymers, fluorinated agents or therapeutic biomolecules, and the appropriate synthetic and/or functionalization strategy must be optimized depending on the nature and characteristics of the functional unit and the type of MOFs. To illustrate the potential and bright future of MOFs in the field of biomedicine, this talk will show an overview of different possibilities through a series of concrete examples focused on different application areas, including MOF-nanoplatforms for the generation of drugs inside cells, phototherapy, renal therapy or hemodialysis, and immune-mediated therapies.
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