Proceedings of MATSUS Spring 2024 Conference (MATSUS24)
DOI: https://doi.org/10.29363/nanoge.matsus.2024.406
Publication date: 18th December 2023
A scaffold designed for tissue engineering should feature biocompatibility, tissue-like mechanical properties, and a hydrated and porous environment. To this end, hydrogels that are 3-dimensional crosslinked polymeric networks are considered excellent scaffolds for tissue engineering [1], with optimal physical and biological characteristics. Further, added functionalities can be incorporated in hydrogels such as electroconductivity, a property critical for electro-responsive tissues such as neural and cardiac tissue [2], self-healing providing the scaffold with mechanical and electronic stability under strain [3], and self-adhesion enabling the placement of the scaffold at the targeted tissue site in a minimally invasive approach [4] . Here, we report the fabrication and characterisation of an adhesive, self-healing, and conductive hydrogel. We show that the hydrogel is porous, has high swelling ratio and is physically stable. We demonstrate its rapid self-healing, and its electroactivity in physiological buffer with both ionic and electronic conduction. Further, its self-adhesion indicates a facile placement on tissues. Coupled together, these properties indicate that the hydrogel with its individual biocompatible components is a suitable scaffold for cell growth and differentiation.
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