Interfacing leaving cells with organic semiconductors

Guglielmo Lanzani^a

^aCompuNet, Istituto Italiano di Tecnologia (IIT), Genova, Genova, Italy

International Conference on Hybrid and Organic Photovoltaics
Proceedings of International Conference on Hybrid and Organic Photovoltaics 2015 (HOPV15)

Roma, Italy, 2015 May 11th - 13th

Organizer: Filippo De Angelis

Invited Speaker, Guglielmo Lanzani, presentation 289
Publication date: 5th February 2015

Selective control of neuronal functions is a mission critical tool in neuroscience and medicine that may enable fundamental science investigation, diagnostic and therapy. Among possible ways to achieve this, stimulation by light has been considered since 1960, for photons do have a number of privileges with respect to electrical stimulation, such as space and time resolution. One major challenge is however the quasi transparency of most neuron cells. This may sounds as a severe limitation, but it is indeed also an opportunity because it allows selective excitation, if a proper sensitization mechanism is available. This talk reports on recent experiments on the photoexcitation of cell lines (HEK 293), astrocytes, neurons and explanted retinas as mediated by a conjugated polymer layer. Conjugated polymers have strong optical absorption, tunable across the whole visible range, are bio compatible, support neutral and charge excitation and can work at the interface with an electrolyte. The development of an artificial retina prosthesis is priority among several applications of this approach. Preliminary results of in vivo retina implants on rats models will be shown.

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