Publication date: 28th June 2024
Introduction: Cardiovascular diseases persist as a significant global health challenge, therefore, for innovative strategies in this area of tissue engineering, this study investigates the blend of bioactive compounds like nanosheets of molybdenum disulfide (MoS2) [1] and the conductive polymer poly(3-hexylthiophene) (P3HT) within double-network (DN) hydrogels tailored for cardiac patch applications that can be activated by light to enhance cellular interactions, self-healing and tissue integration. Results: Using a 3D printer, we created scaffold designs by extruding blends of MoS2(C-P-M) with a coating of P3HT (C-P-M/P3HT). Analysis showed that the incorporation of MoS2 maintained mechanical stiffness comparable to the pure C-P blend, which is critical for structural support in cardiac patches. The later coating of P3HT enables the scaffolds to respond to light stimuli, significantly enhancing the viability and proliferation of Human Umbilical Vein Endothelial Cells (HUVECs) under illuminated conditions, with increases in cell viability observed up to 160%. Discussion: MoS2 nanoparticles contribute to the mechanical stability of the scaffolds while facilitating enhanced cellular responses. The application of P3HT coatings introduces a novel aspect of light responsiveness, allowing for the controlled activation of the scaffolds upon exposure to specific light wavelengths [2]. Conclusions: The combination of MoS2 for structural integrity and P3HT for light-activated functionality within DN hydrogels presents a robust platform for developing bioelectronic interfaces in cardiac tissue engineering. These interfaces not only support mechanical demands but also enable on-demand, light-induced cellular interactions, paving the way for advanced therapeutic strategies in regenerative medicine and tissue engineering.
Beca Doctorado Nacional ANID No. 21201471, ANID-Basal Center of Interventional Medicine for Precision and Advanced Cellular Therapy, IMPACT, Project No. FB210024, Fondecyt Regular No. 1200093.
nanoGe is a prestigious brand of successful science conferences that are developed along the year in different areas of the world since 2009. Our worldwide conferences cover cutting-edge materials topics like perovskite solar cells, photovoltaics, optoelectronics, solar fuel conversion, surface science, catalysis and two-dimensional materials, among many others.
Previously nanoGe Spring Meeting (NSM) and nanoGe Fall Meeting (NFM), MATSUS is a multiple symposia conference focused on a broad set of topics of advanced materials preparation, their fundamental properties, and their applications, in fields such as renewable energy, photovoltaics, lighting, semiconductor quantum dots, 2-D materials synthesis, charge carriers dynamics, microscopy and spectroscopy semiconductors fundamentals, etc.
International Conference on Hybrid and Organic Photovoltaics
International Conference on Hybrid and Organic Photovoltaics (HOPV) is celebrated yearly in May. The main topics are the development, function and modeling of materials and devices for hybrid and organic solar cells. The field is now dominated by perovskite solar cells but also other hybrid technologies, as organic solar cells, quantum dot solar cells, and dye-sensitized solar cells and their integration into devices for photoelectrochemical solar fuel production.
Asia-Pacific International Conference on Perovskite, Organic Photovoltaics and Optoelectronics
The main topics of the Asia-Pacific International Conference on Perovskite, Organic Photovoltaics and Optoelectronics (IPEROP) are discussed every year in Asia-Pacific for gathering the recent advances in the fields of material preparation, modeling and fabrication of perovskite and hybrid and organic materials. Photovoltaic devices are analyzed from fundamental physics and materials properties to a broad set of applications. The conference also covers the developments of perovskite optoelectronics, including light-emitting diodes, lasers, optical devices, nanophotonics, nonlinear optical properties, colloidal nanostructures, photophysics and light-matter coupling.
The International Conference on Perovskite Thin Film Photovoltaics Perovskite Photonics and Optoelectronics (NIPHO) is the best place to hear the latest developments in perovskite solar cells as well as on recent advances in the fields of perovskite light-emitting diodes, lasers, optical devices, nanophotonics, nonlinear optical properties, colloidal nanostructures, photophysics and light-matter coupling.