DOI: https://doi.org/10.29363/nanoge.cybioel.2024.040
Publication date: 28th June 2024
An array of different thiophene-based trimers has been synthesized that combines electronic, chemical, and pharmaceutical functions. These electro-active pharma-materials (e-NP) have been applied onto and into various cell and tissue systems to form seamless bioelectronics that is amalgamated with biology. Selectivity to specific biological components and structures enables us to form well-defined electroactive structures and devices that promise for radically new tools to record and stimulate biological functions, such as neuro-signaling.
In addition, we have developed the organic electronic ion pump that enables the translation of electronic addressing signals into the delivery of bio-relevant ions and charged biomolecules. The OEIP has been developed into different form factors to enable stimulation and therapy targeting a range of neuro-related disorders and diseases.
The objective with the e-NP and the OIEP bioelectronic techniques is to provide minimal invasiveness and selective signal translation at the biology-technology interface.
The fundamentals of, and the results from applications, of the e-NP and OEIP technologies will be reported and discussed.
This work was carried out with funding from the European Research Council (AdG 2018 Magnus Berggren, 834677), the Swedish Research Council (2018-06197), and the Swedish Foundation for Strategic Research (RMX18-0083). Additional funding was provided by the Knut and Alice Wallenberg Foundation and the Önnesjö Foundation.
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