Publication date: 25th July 2016
Cell migration is a key process in several biological contexts such as in development, cancer and wound healing. Current in vitro migration assays lack in the accurate control of important variables that orchestrate cell motility. We developed a system that allows the control of soluble and insoluble factors, as well as the mechanical cues in a high-throughout apparatus. This is achieved by creating dynamically adhesive micropatterned substrates, which allow the binding of specific ECM-mimetic peptides to the patterned polymer brushes via "click chemistry". We adapted and optimised this micro-fabricated system for standard 96-well plate formats and confirmed that cell migration can be reprodicibly induced and quantified by high-content imaging. To demonstrate the utility of this model, we used a collagen mimetic peptide (GFOGER) to activate human keratinocyte migration in the presence of a panel of 150 chromatin modifying compounds and screened for novel epigenetic regulators of re-epithelialisation. In summary, the high-throughput micro-patterned assay described here represents a novel and tuneable system in which to study cell migration, and on-going studies aim to understand how cross-talk between intrinsic and extrinsic factors regulate keratinocyte migration and wound repair.
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